Aggregatibacter actinomycetemcomitans induces Th17 cells in atherosclerotic lesions

Apoptosis in Nonproliferating Macrophages Cytolethal Distending Toxin Induces Aggregatibacter actinomycetemcomitans

An Investigation of Antibiotic Resistance of Aggregatibacter Actinomycetemcomitans and Porphyromonas Gingivalis in Peri-implantitis Lesions

Background and Aim: It has been shown that anaerobic and capnophilic bacteria play an important role in implant failure and loss. The present study is an in vitro research aimed to investigate the antibiotic resistance of Aggregatibacter actinomycetemcomi-tans (Aa) and Porphyromonas gingivalis (Pg) in peri-implantitis lesions of Iranian pa-tients and to find laboratory efficiency of some antibi...

Azithromycin kills invasive Aggregatibacter actinomycetemcomitans in gingival epithelial cells.

Aggregatibacter actinomycetemcomitans invades periodontal pocket epithelium and is therefore difficult to eliminate by periodontal scaling and root planing. It is susceptible to azithromycin, which is taken up by many types of mammalian cells. This led us to hypothesize that azithromycin accumulation by gingival epithelium could enhance the killing of intraepithelial A. actinomycetemcomitans. [...

Mast cells act as phagocytes against the periodontopathogen Aggregatibacter actinomycetemcomitans.

BACKGROUND Evidence to date shows that mast cells play a critical role in immune defenses against infectious agents, but there have been no reports about involvement of these cells in eliminating periodontopathogens. In this study, the phagocytic ability of mast cells against Aggregatibacter actinomycetemcomitans compared with macrophages is evaluated. METHODS In vitro phagocytic assays were ...

Proteomics of Aggregatibacter actinomycetemcomitans Outer Membrane Vesicles

Aggregatibacter actinomycetemcomitans is an oral and systemic pathogen associated with aggressive forms of periodontitis and with endocarditis. Outer membrane vesicles (OMVs) released by this species have been demonstrated to deliver effector proteins such as cytolethal distending toxin (CDT) and leukotoxin (LtxA) into human host cells and to act as triggers of innate immunity upon carriage of ...